Prediction of recombinant Mycobacterium tuberculosis α-crystallin oligomer chaperone activity using polynomial graphs
نویسندگان
چکیده
منابع مشابه
Role of Molecular Interactions and Oligomerization in Chaperone Activity of Recombinant Acr from Mycobacterium tuberculosis
Background: The chaperone activity of Mycobacterium tuberculosis Acr is an important function that helps to prevent misfolding of protein substrates inside the host, especially in conditions of hypoxia. Objectives: The aim of this study was to establish the correlation of structure and function of recombinant Acr proteins both before and after ge...
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The comparison of the chaperone-like activity of native and covalently cross-linked human alphaB-crystallins has confirmed the important role of the subunit mobility in the chaperoning mechanism. Our data clearly demonstrate that the chaperone-like activity of alpha-crystallin is not only a surface phenomenon as was suggested by some researchers.
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Among the products that are expressed when Mycobacterium tuberculosis undergoes hypoxic shiftdown to nonreplicating persistence (NRP) is the alpha-crystallin chaperone protein homologue (Acr). This expression coincides with the previously reported appearance of a respiratory type of nitrate reductase activity, the increase in glycine dehydrogenase activity, and the production of a unique antige...
متن کامل2341 Ageing and the chaperone properties of α-crystallin
w This work aims to test the hypothesis that age-related loss of the molecular chaperone activity of a-crystallin may be involved in the precipitation of lens proteins and subsequent cataract development. &&Q& acrystallins of dierent ages were isolated from concentric tissue layers removed from foetal and adull bovine lenses. They were examined for chaperone activity by measuring their ability ...
متن کاملModulation of α-crystallin chaperone activity in diabetic rat lens by curcumin
α-Crystallin, a small heat shock protein (sHSP), constitutes the major portion of eye lens cytoplasm and its concentration in the lens can reach up to 50% of the total protein. Like other sHSP, α-crystallin displays chaperone-like activity in suppressing the aggregation of various proteins and in preventing inactivation of enzymes due to heat and other stress conditions [1-6]. Hence, in additio...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2018
ISSN: 2046-1402
DOI: 10.12688/f1000research.16328.1